Related Experiment Video
Updated: Jun 9, 2026
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Determinants of preterm neonatal mortality in two rural district hospitals of Gatsibo, Rwanda
Emmanuel Uwambajimana1,2, Albert Ndagijimana3,4, Richard Kalisa5
1Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. wambaemmy@gmail.com.
Background:
Preterm birth remains a critical global health issue, contributing to approximately one-third of neonatal deaths worldwide. In Rwanda, complications of preterm birth contributed to the second cause on neonatal mortality with specifically two district hospitals (i.e. Kiziguro and Ngarama) located in Gatsibo district reported threefold higher preterm neonatal mortality as compared to national average. We aimed to determine the proportion and determinants of preterm neonatal mortality in two rural hospitals in Gatsibo district, Rwanda.
Methods:
We conducted a retrospective cross-sectional study using records of all preterm neonates admitted to Kiziguro and Ngarama hospital neonatal units, between January 2020 and December 2024. Data were extracted from neonatal files and maternity registers. Descriptive statistics were used to describe the study variables. Bivariate and multivariable logistic regression analyses were conducted to identify the determinants of preterm neonatal mortality. We reported odds ratios, 95% CIs, and p values, and we set the significance at the 95% confidence level.
Results:
The majority of preterm deaths occurred at Kiziguro district hospital (21.0%, n = 1217). The determinants of preterm neonatal mortality were early gestational age (aOR = 2.47, 95% CI: 1.30-4.65), neonatal sepsis (aOR = 3.35, 95% CI: 1.98-5.69), hypothermia (aOR = 1.72, 95% CI: 1.12-2.66), need for special care unit services (aOR = 5.32, 95% CI: 2.61-11.96), poor respiratory support (aOR = 7.63; 95% CI: 3.69-15.80), poor bilirubin management (aOR = 2.82, 95% CI: 1.50-5.27), and inadequate kangaroo mother care practices (aOR = 51.82, 95% CI: 31.77-84.51).
Conclusion:
The proportion of preterm mortality was approximately similar to the national figures. Key determinants associated with preterm neonatal mortality included: early gestational age, maternal infections, inadequate kangaroo mother care (KMC), neonatal sepsis and inadequate respiratory support. Thus, continuous neonatal capacity building, improved KMC practices, appropriate use of neonatal equipment and regular cleanliness are recommended.
