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Related Concept Videos

Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
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Updated: Jun 9, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
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Migration-Associated Variation in Gastric Cancer Risk in the United States: Implications for Risk Stratification.

Chul S Hyun1, Rong Wang2, Sung Hwi Hong3

  • 1Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.

International Journal of Cancer
|June 8, 2026
PubMed
Summary
This summary is machine-generated.

Gastric cancer risk remains higher in Asian immigrant populations in the U.S. compared to non-Hispanic Whites. These migration-associated risk differences persist, highlighting the need for tailored prevention strategies.

Keywords:
Asian populationsgastric cancerincidencemigrationrisk stratification

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Area of Science:

  • Epidemiology
  • Cancer Research
  • Public Health

Background:

  • Migrant studies show reduced gastric cancer risk post-migration, but not full convergence to host country levels.
  • Early-life exposures and long disease latency are implicated in persistent gastric cancer risk.
  • Contemporary evaluation of migration-associated gastric cancer risk gradients in low-incidence settings is needed.

Purpose of the Study:

  • To assess if migration-associated gastric cancer risk gradients are detectable in contemporary U.S. low-incidence settings.
  • To analyze gastric cancer incidence trends among Asian subgroups in California and New York.
  • To contextualize U.S. incidence with country-of-origin rates and extrapolate future trends.

Main Methods:

  • Analysis of SEER and state cancer registry data (2010-2022) linked to U.S. Census denominators.
  • Estimation of crude and age-adjusted gastric cancer incidence rates.
  • Disaggregation of Asian populations into Chinese, Japanese, Korean, and Vietnamese subgroups; Joinpoint regression for temporal trends.

Main Results:

  • Gastric cancer incidence was consistently higher in Asian populations (12-26 per 100,000) than non-Hispanic Whites (3.6-4.7 per 100,000).
  • Korean populations showed the highest incidence among Asian subgroups.
  • Incidence declined in California (~-1% to -3% annually) but not in New York; projections indicate a persistent burden through 2035.

Conclusions:

  • Migration-associated variations in gastric cancer risk are detectable and relevant for prevention in the U.S.
  • Persistent risk gradients underscore the need for migration-informed risk stratification.
  • Tailored prevention strategies are crucial for high-risk immigrant subgroups.