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Related Experiment Video

Updated: Jun 9, 2026

Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Anisodamine Hydrobromide Ameliorates Pulmonary Microcirculatory Dysfunction in Septic Rats.

Yan-Chen Liu1,2,3, Ting-Ting Xie1,2, Xiao-Yi Wang1,2

  • 1Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China.

Microcirculation (New York, N.Y. : 1994)
|June 8, 2026
PubMed
Summary

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This summary is machine-generated.

Anisodamine hydrobromide (ADM) improves survival in septic rats by protecting pulmonary microcirculation. It reduces inflammation and preserves blood vessel integrity, offering potential for treating sepsis-induced lung injury.

Area of Science:

  • Pulmonary Medicine
  • Pharmacology
  • Critical Care Medicine

Background:

  • Sepsis causes pulmonary microcirculatory dysfunction, leading to hypoxemia and organ failure.
  • Anisodamine hydrobromide (ADM) is used in China for septic shock but its lung effects are unclear.

Purpose of the Study:

  • To investigate the effects of ADM on pulmonary microcirculatory dysfunction in a rat model of sepsis.

Main Methods:

  • Sepsis induced by cecal ligation and puncture (CLP) in rats.
  • Treatment with varying doses of ADM.
  • Assessment of survival, blood gases, microvascular leakage, inflammation, endothelial junctions, and matrix metalloproteinases.

Main Results:

  • ADM improved survival and blood oxygen levels in septic rats.
Keywords:
anisodamine hydrobromideleukocyte adhesionmicrovascular hyperpermeabilitypulmonary microcirculation dysfunctionsepsis

Related Experiment Videos

Last Updated: Jun 9, 2026

Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

  • ADM reduced pulmonary edema, microvascular leakage, and inflammatory cell infiltration.
  • ADM preserved endothelial junction proteins and basement membrane integrity while downregulating MMP-9.

    • Conclusions:

    • ADM protects against sepsis-induced pulmonary microcirculation dysfunction.
    • ADM attenuates inflammation and maintains vascular integrity.
    • ADM shows therapeutic potential for sepsis-related lung injury.