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Published on: February 8, 2013
Anisodamine Hydrobromide Ameliorates Pulmonary Microcirculatory Dysfunction in Septic Rats
Yan-Chen Liu1,2,3, Ting-Ting Xie1,2, Xiao-Yi Wang1,2
1Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China.
Microcirculation (New York, N.Y. : 1994)
|June 8, 2026
Summary
Anisodamine hydrobromide (ADM) improves survival in septic rats by protecting pulmonary microcirculation. It reduces inflammation and preserves blood vessel integrity, offering potential for treating sepsis-induced lung injury.
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Critical Care Medicine
Background:
- Sepsis causes pulmonary microcirculatory dysfunction, leading to hypoxemia and organ failure.
- Anisodamine hydrobromide (ADM) is used in China for septic shock but its lung effects are unclear.
Purpose of the Study:
- To investigate the effects of ADM on pulmonary microcirculatory dysfunction in a rat model of sepsis.
Main Methods:
- Sepsis induced by cecal ligation and puncture (CLP) in rats.
- Treatment with varying doses of ADM.
- Assessment of survival, blood gases, microvascular leakage, inflammation, endothelial junctions, and matrix metalloproteinases.
Main Results:
- ADM improved survival and blood oxygen levels in septic rats.
- ADM reduced pulmonary edema, microvascular leakage, and inflammatory cell infiltration.
- ADM preserved endothelial junction proteins and basement membrane integrity while downregulating MMP-9.
Conclusions:
- ADM protects against sepsis-induced pulmonary microcirculation dysfunction.
- ADM attenuates inflammation and maintains vascular integrity.
- ADM shows therapeutic potential for sepsis-related lung injury.