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Updated: Jun 9, 2026

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Anisodamine Hydrobromide Ameliorates Pulmonary Microcirculatory Dysfunction in Septic Rats.

Yan-Chen Liu^1,2,3, Ting-Ting Xie^1,2, Xiao-Yi Wang^1,2

¹Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China.

Microcirculation (New York, N.Y. : 1994)

|June 8, 2026

Summary

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Anisodamine hydrobromide (ADM) improves survival in septic rats by protecting pulmonary microcirculation. It reduces inflammation and preserves blood vessel integrity, offering potential for treating sepsis-induced lung injury.

Area of Science:

Pulmonary Medicine
Pharmacology
Critical Care Medicine

Background:

Sepsis causes pulmonary microcirculatory dysfunction, leading to hypoxemia and organ failure.
Anisodamine hydrobromide (ADM) is used in China for septic shock but its lung effects are unclear.

Purpose of the Study:

To investigate the effects of ADM on pulmonary microcirculatory dysfunction in a rat model of sepsis.

Main Methods:

Sepsis induced by cecal ligation and puncture (CLP) in rats.
Treatment with varying doses of ADM.
Assessment of survival, blood gases, microvascular leakage, inflammation, endothelial junctions, and matrix metalloproteinases.

Main Results:

ADM improved survival and blood oxygen levels in septic rats.

Keywords:

anisodamine hydrobromide leukocyte adhesion microvascular hyperpermeability pulmonary microcirculation dysfunction sepsis

Related Experiment Videos

Last Updated: Jun 9, 2026

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

ADM reduced pulmonary edema, microvascular leakage, and inflammatory cell infiltration.

ADM preserved endothelial junction proteins and basement membrane integrity while downregulating MMP-9.

Conclusions:

ADM protects against sepsis-induced pulmonary microcirculation dysfunction.
ADM attenuates inflammation and maintains vascular integrity.
ADM shows therapeutic potential for sepsis-related lung injury.