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Updated: Jun 9, 2026
04:41
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Revisiting Spontaneous Keloids: Aetiology, Genetics and Evidence for a Polygenic Pathogenesis
Anuj Budhiraja1,2, Harrison Shawa2,3, Alisha Mehta1,2
1College of Medicine, California Northstate University, Elk Grove, California, USA.
Summary
Spontaneous keloids, unlike typical scars, may stem from internal genetic factors, not just injury. This study explores these rare cases, suggesting polygenic dysregulation in wound healing pathways.
Area of Science:
- Dermatology
- Genetics
- Pathology
Background:
- Keloids are abnormal scars that grow beyond the original wound.
- While usually caused by injury, rare spontaneous keloids suggest other causes.
- Understanding these rare cases is crucial for diagnosing and managing keloid disorders.
Purpose of the Study:
- To synthesize all reported cases of spontaneous keloids.
- To explore the pathogenic mechanisms behind diverse keloid etiologies.
- To highlight syndromic disorders associated with spontaneous keloids and inform genetic decision-making.
Main Methods:
- Systematic literature review of spontaneous keloid cases.
- Analysis of clinical and genetic data from reported cases.
- Bioinformatic analysis of genetic testing results from a representative case.
Main Results:
- Identified rare cases of keloids forming without apparent injury.
- Highlighted syndromic associations and potential genetic underpinnings.
- Uncovered candidate genes suggesting a polygenic model for keloid formation.
Conclusions:
- Keloid formation may be a primary manifestation of polygenic dysregulation, not just a response to trauma.
- Spontaneous keloids offer insights into the complex genetic basis of wound healing.
- Further research into genetic factors is essential for understanding and treating keloids.
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