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Published on: February 25, 2022

Vascular Disease Prospective-Retrospective Observational Registry for Aortic Aneurysm and Peripheral Artery Disease

Ju Yeon Choi1,2, Tae Oh Kim3, Jun Gyo Gwon1

  • 1Division of Vascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Vascular Specialist International
|June 8, 2026
PubMed

Insights

The VAPOR registry in Korea collects integrated data on peripheral artery disease (PAD) and aortic aneurysm (AA) to improve vascular care. This real-world evidence supports precision medicine and better patient outcomes for atherosclerosis.

Area of Science:

  • Vascular Surgery
  • Cardiovascular Research
  • Epidemiology

Background:

  • Peripheral artery disease (PAD) and aortic aneurysm (AA) are significant manifestations of systemic atherosclerosis.
  • Despite shared risk factors and pathways, integrated long-term data for both conditions are limited in Korea.
  • This data scarcity hinders real-world evidence generation and outcome evaluation for vascular diseases.

Purpose of the Study:

  • To establish the Vascular disease Prospective-Retrospective Observational Registry (VAPOR) in Korea.
  • To systematically collect clinical, imaging, and procedural data for patients with AA and PAD.
  • To identify shared and disease-specific risk factors, evaluate outcomes, and support precision vascular medicine.

Main Methods:

  • VAPOR is a mixed retrospective-prospective registry, initially single-centered with plans for multicenter expansion.
  • It collects comprehensive data on patients diagnosed with AA and/or PAD.
  • The registry is designed to facilitate risk stratification and the development of an interoperable vascular data infrastructure.

Main Results:

  • As of April 15, 2026, VAPOR enrolled 5,249 patients (4,438 retrospective, 811 prospective).
  • The cohort includes 2,193 patients with AA, 3,287 with PAD, and 231 with both conditions.
  • Primary outcomes focus on major adverse cardiovascular and limb events, alongside aneurysm/procedure-related events.

Conclusions:

  • The VAPOR registry offers a valuable real-world dataset for assessing treatment outcomes and long-term prognoses in patients with AA or PAD.
  • Its integrated retrospective and prospective data, with multicenter expansion potential, is a significant advancement for Korean vascular surgery.
  • VAPOR is poised to enhance evidence-based management and promote precision vascular care.
Abstract

Keywords:
Aortic aneurysmCohort studyPeripheral artery diseaseReal-world evidenceRegistry

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