Modeling Rare Events and Nonmonotone Nonignorable Missingness of Time-Varying Outcomes and Predictors in Binary...

This study investigates the relationship between daily interpersonal stress (binary, time-varying) and suicidal behavior (binary, time-varying) using 90 days of daily diary data from 106 adolescents assessed immediately after discharge from acute psychiatric treatment. It addresses two key complexities: the rarity of suicidal events and non-monotone, non-ignorable missingness in both the outcome and the predictor. Because existing methods often fail to accommodate these complexities, leading to biased estimates, a Bayesian selection model is specified. The model integrates a mixed-effects complementary log-log regression for rare events with a missingness model that accounts for non-monotone, non-ignorable missingness in the outcome. A probit mixed-effects model is used for the time-varying predictor, along with a corresponding missingness model for its non-monotone, non-ignorable missingness. Empirical results support the applicability of the specified model to longitudinal studies involving rare events and complex missing-data structures. Furthermore, a simulation study demonstrates parameter recovery and highlights bias in focal parameters when sensitivity parameters in the outcome and missingness models are ignored.