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Updated: Jun 9, 2026
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Temporal Trends and Future Projections of Osteoarthritis Knee Burden in China: Analysis of GBD 2021
Fan Yang1,2, Qingmeng Zhang3, Jiying Chen2,4
1Department of Joint Surgery, Beijing Jishuitan Hospital Liaocheng Hospital, Liaocheng, Shandong Province, China.
Background:
Knee osteoarthritis (OA), a leading cause of disability, disproportionately affects women and the elderly, contributing significantly to health burdens. This study aims to analyze the temporal trend and future projection of knee OA burden in China, using data from the Global Burden of Disease (GBD) 2021.
Methods:
The research employed age-period-cohort (APC) and autoregressive integrated moving average (ARIMA) models to examine the effects of age, period, and cohort on the incidence and disability-adjusted life years (DALYs) of knee OA from 1990 to 2021, with projections for the next 15 years.
Results:
Findings show a substantial increase in knee OA incidence and DALYs over the past three decades, particularly among women, with a notable age-dependent rise. The ARIMA model predicts a gradual decline in knee OA incidence and DALYs after 2021, potentially due to healthcare reforms and preventive strategies.
Conclusion:
The study underscores the growing healthcare burden of knee OA in China and highlights the need for effective prevention, early diagnosis, and improved healthcare infrastructure to manage this increasing public health issue.
