Related Experiment Video
Updated: Jun 9, 2026
12:07
Laparoscopic Radical Antegrade Modular Pancreatosplenectomy via Dorsal-Caudal Artery Approach for Pancreatic Neck-Body Cancer
Published on: November 18, 2022
Periarterial Divestment in Locally Advanced Pancreatic Cancer: Systematic Review and Single-Arm Meta-Analysis
Philipe Franco do Amaral Tafner1, Júlia Paiva Behs1, Fernanda de Moraes Nava1
1Department of Surgery, Heliopolis Hospital, São Paulo, Brazil.
Summary
Periarterial divestment offers an artery-preserving approach for pancreatic cancer, showing varied perioperative and oncologic outcomes. However, current evidence is descriptive and lacks comparative data for definitive conclusions.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Oncology
Background:
- Periarterial divestment is an artery-preserving surgical technique for pancreatic cancer.
- Evidence on its outcomes is limited, particularly for borderline resectable and locally advanced cases.
- This study evaluates perioperative and oncologic results of periarterial divestment.
Purpose of the Study:
- To systematically review and evaluate the perioperative and oncologic outcomes of periarterial divestment in pancreatic cancer patients.
- To synthesize available evidence on the safety and efficacy of this artery-preserving approach.
- To identify key outcomes including complications, survival rates, and resection margins.
Main Methods:
- Systematic review of studies published up to March 2026 using major scientific databases (PubMed, Scopus, Web of Science, Cochrane).
- Meta-analysis of continuous outcomes (means with 95% CIs) and binary outcomes (proportions) using random-effects models.
- Assessment of heterogeneity with I² statistic and Cochrane Q test; sensitivity analyses using leave-one-out methods; analysis in R version 4.4.2.
Main Results:
- Included 5 retrospective studies with 474 patients, mostly with locally advanced pancreatic cancer (92.8%) and neoadjuvant therapy (64.8%).
- Pooled data showed operative time 333.0 min, blood loss 620.6 mL, and hospital stay 12.4 days, with high heterogeneity.
- Reported complication rates included intraabdominal infection (10.57%), pancreatic fistula (8.72%), and major complications (11.27%); R0 resection rate was 43.33%; 1-year and 3-year overall survival rates were 75.99% and 29.11% respectively.
Conclusions:
- Periarterial divestment has been applied in selected pancreatic cancer patients, with documented perioperative and oncologic outcomes.
- The existing evidence is primarily descriptive and does not support comparative inferences between different surgical approaches.
- Further research is needed to establish the comparative effectiveness and role of periarterial divestment in pancreatic cancer management.
