Related Experiment Video

Updated: Jun 9, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

A Systematic Review On ERK/MAPK Signaling Circuit As The Critical Regulator In Chronic Wound Healing: Phytochemicals

Krishnendu Adhikary1, Saurav Barman2, Riya Sarkar3

  • 1Department of Interdisciplinary Science, Centurion University of Technology and Management, Bhubaneswar, Odisha, 752050, India.

Mini Reviews in Medicinal Chemistry
|June 8, 2026
PubMed
Abstract

Insights

The ERK/MAPK pathway is crucial for wound healing and scar formation. Targeting this pathway with phytomedicines shows promise for treating chronic wounds, especially in diabetes.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Dermatology

Background:

  • Wound healing involves complex cellular processes like migration and proliferation.
  • Pathological conditions, including diabetes, impair natural wound healing.
  • The ERK/MAPK pathway is a key regulator of both wound repair and scar formation.

Purpose of the Study:

  • To review the role of the ERK/MAPK pathway in chronic wound healing.
  • To explore phytomedicines targeting the ERK/MAPK cascade for therapeutic potential.

Main Methods:

  • Critical literature review using PRISMA guidelines.
  • Analysis of public databases for ERK pathway involvement in wound healing.
  • Screening of phytomedicines for ERK/MAPK modulation.

Main Results:

  • The ERK/MAPK pathway governs inflammation, cell migration, proliferation, and collagen deposition in wound healing.
  • Specific natural compounds and extracts can modulate ERK signaling.

Conclusions:

  • Phytotherapy targeting ERK/MAPK can promote healing over scar formation in chronic wounds.
  • Natural remedies like lemongrass and aloe vera show potential.
  • Further research is needed to fully understand ERK isoforms and develop precise therapies.
Keywords:
ERK/MAPKchronic wound healingdiabetesepidermal growth factorinflammationphytochemicals.reactive oxygen species

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