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Related Experiment Video

Updated: Jun 9, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Image-Guided Dual Magnetic-Photothermal Hyperthermia Using a Multifunctional Fe3O4-PANI-GQD Biomaterial Platform.

Mohammad Suhaan Dar1, Niroj Kumar Sahu2

  • 1Centre for Nanotechnology Research, Vellore Institute of Technology, Vellore 632014, India.

ACS Applied Bio Materials
|June 8, 2026
PubMed
Summary

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A novel magneto-photothermal nanoplatform effectively treats triple-negative breast cancer (TNBC) using combined hyperthermia. This image-guided therapy shows significant tumor regression with minimal toxicity, offering a promising approach for cancer treatment.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Triple-negative breast cancer (TNBC) presents significant therapeutic challenges due to a lack of targeted treatments and frequent recurrence.
  • Existing therapies for TNBC are limited, necessitating the development of innovative treatment strategies.

Purpose of the Study:

  • To develop and evaluate a multifunctional magneto-photothermal nanoplatform (FPG) for image-guided combined hyperthermia therapy.
  • To assess the efficacy and safety of the FPG nanoplatform in treating TNBC both in vitro and in vivo.

Main Methods:

  • Engineered a nanoplatform (FPG) comprising a magnetic Fe3O4 core, a near-infrared (NIR)-absorbing polyaniline shell, and fluorescent graphene quantum dots.
  • Investigated FPG's properties, including colloidal stability, superparamagnetism, and NIR absorption.
Keywords:
TNBCcombined hyperthermiagraphene quantum dotsmagneto-photothermal therapypolyanilinetheranostics

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  • Evaluated hyperthermia efficacy under alternating magnetic field (AMF) and NIR laser irradiation in vitro.
  • Assessed FPG-induced cytotoxicity in MDA-MB-231 TNBC cells.
  • Conducted in vivo studies using image-guided combined hyperthermia therapy in a tumor model.
  • Developed an integrated AMF-NIR prototype system for translational feasibility.

    • Main Results:

    • FPG exhibited excellent colloidal stability, retained superparamagnetism, and showed strong NIR absorption.
    • FPG effectively raised suspension temperatures within the therapeutic hyperthermia range under AMF and NIR exposure.
    • Concentration-dependent cytotoxicity was observed in MDA-MB-231 cells, with enhanced tumor suppression under combined AMF and NIR treatment.
    • In vivo studies demonstrated significant tumor regression with minimal systemic toxicity, confirmed by histopathology and serum biochemistry.
    • The integrated prototype system confirmed translational feasibility for synchronized heating with feedback control.

    Conclusions:

    • The developed FPG nanoplatform is a promising tool for image-guided combined magneto-photothermal hyperthermia therapy against TNBC.
    • Rational interface engineering of multifunctional biomaterials enables effective and safe translational cancer therapy.
    • This approach offers a potential new avenue for treating challenging cancers like TNBC.