Design Principles, Synthetic Strategies, and Biomedical Applications of Peptide-Polymer Conjugates.

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Pharmaceutical Chemistry

Background:

• Peptides offer high selectivity and biocompatibility for drug development.
• Poor in vivo stability and short half-life limit peptide therapeutic applications.
• Peptide-polymer conjugates improve pharmacokinetic properties and therapeutic efficacy.

Purpose of the Study:

• To systematically review the design principles and synthetic strategies of peptide-polymer conjugates.
• To elaborate on the applications of these conjugates in drug delivery, immunotherapy, and tissue engineering.
• To discuss current challenges and future prospects for peptide-based therapeutics.

Main Methods:

• Review of covalent bonding, physical association, and self-assembly conjugation mechanisms.
• Analysis of applications in drug delivery, immunotherapy, and tissue engineering.
• Discussion of challenges like conjugation site control and immunogenicity.

Main Results:

• Peptide-polymer conjugation significantly enhances in vivo stability and therapeutic efficacy.
• Diverse synthetic strategies enable tailored conjugate properties.
• Applications span drug delivery, immunotherapy, and tissue engineering.

Conclusions:

• Peptide-polymer conjugates are a promising strategy to overcome limitations of peptide therapeutics.
• Controlling conjugation sites and managing immunogenicity are key challenges.
• Development of responsive intelligent systems is envisioned for clinical translation.