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Updated: Jun 9, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

Enzyme-Integrated Hydrogels for Advanced Biological Applications.

Min Hu¹, Yujing Tang², Xingyue He²

¹School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Polymer Science & Technology (Washington, D.C.)

|June 8, 2026

Summary

This summary is machine-generated.

Enzyme-integrated hydrogels leverage natural enzymes for biocatalysis. This review covers their construction, advanced strategies, and diverse biomedical applications, highlighting future opportunities in diagnostics and therapeutics.

Keywords:

Biocatalysis Biocompatibility Biomedical diagnostics Enzyme-integrated hydrogel Immobilization techniques

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Last Updated: Jun 9, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

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Published on: August 4, 2017

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Published on: June 7, 2015

Area of Science:

Biomaterials Science
Biocatalysis
Enzyme Engineering

Background:

Natural enzymes offer high catalytic efficiency due to precise structure and metabolic pathway compartmentalization.
Enzyme-integrated hydrogels are inspired by natural systems for advanced biocatalysis.

Purpose of the Study:

To systematically review strategies for constructing enzyme-integrated hydrogel systems.
To elaborate on enzyme-mediated polymerization and cross-linking techniques.
To highlight diverse biomedical applications and future perspectives of these hydrogels.

Main Methods:

Discussion of physical strategies: self-assembly, electrostatic adsorption, and direct encapsulation.
Elaboration on enzyme-mediated self-confined polymerization and cross-linking.
Review of enzyme cascades, nanozymes, and physical-biochemical coupling catalysis.

Main Results:

Enzyme-integrated hydrogels can be constructed using various physical and biochemical strategies.
These hydrogels demonstrate significant potential in imaging, tumor therapy, and tissue engineering.
Diverse applications in biomedical diagnostics and therapeutics are enabled by these advanced systems.

Conclusions:

Enzyme-integrated hydrogels represent a promising platform for advanced biocatalysis and biomedical applications.
Further research is needed to address current challenges and unlock the full potential for clinical translation.
Continued development will expand their use in diagnostics, therapeutics, and regenerative medicine.