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Expert Consensus on the Clinical Application of Poly ADP Ribose Polymerase Inhibitors in Breast Cancer (2025 Edition)

Fei Ma1, Binghe Xu1,

  • 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.

Cancer Innovation
|June 8, 2026
PubMed

Insights

Poly ADP-ribose polymerase (PARP) inhibitors offer a new precision therapy for breast cancer by exploiting DNA repair defects. This consensus guides their safe and effective clinical use in China.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Breast cancer incidence is rising in China, increasing the need for advanced treatments.
  • Poly ADP-ribose polymerase (PARP) inhibitors represent a novel therapeutic class targeting DNA damage repair.
  • BRCA1/2 mutations are key indicators for PARP inhibitor efficacy in breast cancer.

Purpose of the Study:

  • To provide guidance on the standardized application of PARP inhibitors in breast cancer treatment.
  • To outline safety management strategies for PARP inhibitors in clinical practice.
  • To serve as a reference for healthcare professionals based on current evidence.

Main Methods:

  • Review of latest evidence-based medical data.
  • Consensus development among experts.
  • Focus on clinical application and safety.

Main Results:

  • PARP inhibitors induce synthetic lethality in BRCA-mutated breast cancer cells.
  • Approved PARP inhibitors like Olaparib and Fluzoparib show significant efficacy.
  • Standardized application protocols are crucial for optimal outcomes.

Conclusions:

  • PARP inhibitors are a valuable option for precision therapy in breast cancer.
  • Evidence-based guidance is essential for safe and effective use.
  • This consensus aims to improve breast cancer management in China.
Keywords:
PARP inhibitorsbreast cancerclinical applicationsafety managementtargeted therapy

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