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Related Concept Videos

Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 9, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Gastric Cancer: Pathobiology and Therapeutics.

Ruixian Yu1, Miao Zhang2, Yan Meng2

  • 1State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences Department of General Surgery, QingPu Branch of Zhongshan Hospital, Fudan University Shanghai China.

Medcomm
|June 8, 2026
PubMed
Summary

Gastric cancer (GC) research is advancing rapidly, focusing on molecular drivers and the tumor microenvironment to improve therapies. Integrating deep profiling, neural-immune modulation, and AI will personalize treatments and overcome resistance for better patient outcomes.

Keywords:
gastric cancerimmunotherapymolecular classificationneural regulationtargeted therapytumor microenvironment

More Related Videos

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

Related Experiment Videos

Last Updated: Jun 9, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
03:05

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

Area of Science:

  • Oncology and Molecular Biology
  • Immunology
  • Computational Biology

Background:

  • Gastric cancer (GC) presents significant challenges due to molecular heterogeneity and late diagnosis.
  • Current therapies offer limited durable responses, necessitating novel treatment strategies.

Purpose of the Study:

  • To review recent multidisciplinary advances in gastric cancer research.
  • To highlight emerging therapeutic strategies and translational barriers.

Main Methods:

  • Consolidation of updated histopathological and molecular classifications.
  • Examination of tumor biology, microenvironment dynamics, and therapeutic innovations.
  • Discussion of novel technologies like multiomics and AI-enabled computational oncology.

Main Results:

  • Identification of key oncogenic programs (e.g., Hippo-YAP signaling, neural-stem cell interactions).
  • Analysis of the immunosuppressive tumor microenvironment and its role in resistance.
  • Evaluation of emerging therapies including targeted agents, immune checkpoint blockade, and cellular therapies.

Conclusions:

  • Precision medicine for GC requires integrating molecular profiling, neural-immune modulation, and AI.
  • Developing mechanism-based combination therapies is crucial to overcome resistance and improve patient outcomes.