Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary cutaneous adenoid cystic carcinoma of the right forearm: a case report and dermoscopic features.

Frontiers in medicine·2026
Same author

Correction to "Living Therapeutic Microneedles Integrated with Built-In Metabolic Engines for Autonomous Diabetic Wound Management".

Nano letters·2026
Same author

The emerging roles of alternative splicing in modulating tumor immune responses and immunotherapies.

Cell death and differentiation·2026
Same author

Targeting SRSF6 to Enhance Cisplatin Sensitivity by Modulating Redox Balance via NFE2L1 exon 4 Splicing in ESCC.

International journal of biological sciences·2026
Same author

Global landscape of protein-coding and long non-coding RNA alternative splicing and regulation in the human esophageal squamous cell carcinoma.

Cancer cell international·2026
Same author

Public antibody clonotypes and deep learning identify SARS-CoV-2 and HIV broadly neutralizing antibodies in immune repertoires.

Cell reports·2026
Same journal

A C3 Radical Copolymerization.

Polymer science & technology (Washington, D.C.)·2026
Same journal

Recyclable Photopolymers for Sustainable 3D Printing.

Polymer science & technology (Washington, D.C.)·2026
Same journal

Polysaccharide-Based Encapsulation of Microbes for Enhanced Microbial Therapy.

Polymer science & technology (Washington, D.C.)·2026
Same journal

Sustainable and High-Performance Polylactide/Polycarbonate Blends with Enhanced Toughness and Thermal Stability via Stereocomplexation and Phase Continuity.

Polymer science & technology (Washington, D.C.)·2026
Same journal

Cross-Conjugated Donor-Acceptor Polymers for High-Performance Organic Electrochemical Transistors.

Polymer science & technology (Washington, D.C.)·2026
Same journal

pH-Ultrasensitive Polyester Nanoprobe for High-Contrast Tumor Imaging with Superior Biocompatibility.

Polymer science & technology (Washington, D.C.)·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers.

Ran Chen1, Yaping Liu1, Yanan Jiang1

  • 1Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.

Polymer Science & Technology (Washington, D.C.)
|June 8, 2026
PubMed
Summary
This summary is machine-generated.

Polymer materials offer promising strategies for membrane-targeted cancer therapy and antimicrobial treatments. Researchers are designing polymers to target cell and organelle membranes, enhancing drug delivery and reducing side effects.

Keywords:
antibacterialantitumorbiological membranedrug deliverymembrane-targeted polymers

More Related Videos

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.
11:10

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.

Published on: April 5, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.
11:10

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.

Published on: April 5, 2018

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanomedicine

Background:

  • Membrane structures are vital for cellular functions, including material exchange and signal transduction.
  • Membrane-targeting strategies are increasingly important in cancer therapy and antimicrobial research.
  • Polymer materials exhibit biocompatibility and tunability, making them suitable for targeted therapies.

Purpose of the Study:

  • To review design strategies for polymer materials targeting cell and organelle membranes.
  • To explore the potential of polymers in enhancing membrane-targeted therapeutics.
  • To discuss challenges and future directions in the field.

Main Methods:

  • Analysis of tumor cell membranes, organelle membranes, and bacterial cell walls for targeting.
  • Design of polymer materials by adjusting charge density and hydrophilicity/hydrophobicity.
  • Utilizing cationic polymers and functionalized polymers for targeted membrane interactions.

Main Results:

  • Cationic polymers can disrupt membrane integrity, facilitating cytosolic delivery.
  • Functionalized polymers enable specific membrane recognition, reducing off-target effects.
  • Modified polymers have shown up to a 10-fold increase in cellular uptake efficiency.

Conclusions:

  • Polymer design offers versatile approaches for membrane-targeted therapeutics.
  • Targeted polymer strategies can improve drug delivery and therapeutic efficacy.
  • Further research is needed to overcome challenges and advance precise disease management.