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Minocycline-induced Hyperpigmentation of Transplanted Free Flaps: A Case Report
Daiju Goto1, Azusa Oshima1, Kiichi Furuse1
1Department of Plastic and Reconstructive Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Journal of Plastic and Reconstructive Surgery
|June 8, 2026
Summary
Minocycline can cause blue discoloration in transplanted head and neck free flaps. This side effect, previously seen on skin and mucosa, is now reported in intraoral reconstructions.
Area of Science:
- Oral and Maxillofacial Surgery
- Plastic Surgery
- Dermatology
Background:
- Minocycline is known to cause hyperpigmentation on skin and mucosa.
- Free flaps are commonly used in head and neck reconstruction.
- Cetuximab is often used in postoperative chemotherapy for head and neck cancers.
