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Updated: Jun 9, 2026
08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
Tumor infiltrating lymphocytes against solid tumors: current trends & perspectives.
Ze Min Liew1, Yu Shyan Low1, Khang Chiang Oh1
1Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.
Peerj
|June 8, 2026
Summary
Tumor-infiltrating lymphocytes (TILs) are crucial for anticancer immunity and prognosis. This review details TIL populations, their roles in the tumor microenvironment (TME), and strategies to enhance TIL infiltration for better cancer treatment outcomes.
Area of Science:
- Immunology
- Oncology
- Cancer Biology
Background:
- Tumor-infiltrating lymphocytes (TILs) are vital for anti-cancer immunity.
- TILs significantly impact cancer progression and patient prognosis.
- The tumor microenvironment (TME) composition dictates immune cell activity.
Purpose of the Study:
- To review current knowledge on diverse TIL populations and their functions in cancer immunity.
- To explore factors influencing immune cell infiltration into solid tumors.
- To propose novel immunotherapeutic strategies for enhancing TIL infiltration.
Main Methods:
- Comprehensive literature review of TILs in cancer immunity.
- Analysis of factors affecting immune cell homing and infiltration.
- Synthesis of recent immunotherapeutic approaches targeting TILs.
Main Results:
- TILs play a dual role, with both anti-tumorigenic and pro-tumorigenic populations identified.
- The balance of immune cells within the TME is a key determinant of tumor fate.
- Factors influencing TIL infiltration are critical for effective anti-cancer immune responses.
Conclusions:
- Understanding TIL properties and TME dynamics is essential for cancer immunotherapy.
- Strategies to improve TIL infiltration hold promise for enhancing clinical outcomes.
- Targeting immune cell infiltration represents a promising avenue for novel cancer therapies.
Keywords:
ChemokinesImmunotherapySolid tumorTumor immunologyTumor infiltrating lymphocytesTumor microenvironmentMore Related Videos
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