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Midodrine hydro-chloride Form A, C12H19N2O4 +·Cl
Jacob K Salazar1, James A Kaduk2,3, Anja Dosen4
1North Central College, Department of Chemistry 131 S Loomis St Naperville IL 60540 USA.
None:
The crystal structure of midodrine hydro-chloride Form A (systematic name: {[2-(2,5-di-meth-oxy-phen-yl)-2-hy-droxy-eth-yl]carbamo-yl}methanaminium chloride, C12H19N2O4 +·Cl-) has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory techniques. Midodrine hydro-chloride Form A crystallizes in space group P21/c (#14). The crystal structure is characterized by layers perpendicular to the c-axis direction. The Cl anions reside in the center of the layer. Hydrogen bonds are prominent in the structure. Each of the three H on the protonated N acts as a donor - one to the carbonyl group and the other two to the Cl ion. The hydroxyl group and the amide also act as donors to Cl. Considering the classical hydrogen bonds, the Cl ion is four-coordinate.
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