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Updated: Jun 9, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
Avutometinib
Jacob K Salazar1, James A Kaduk2,3, Anja Dosen4
1North Central College, Department of Chemistry 131 S Loomis St Naperville IL 60540 USA.
Abstract:
The crystal structure of avutometinib (systematic name: 3-{[3-fluoro-2-(methyl-sulfamoyl-amino)-pyridin-4-yl]meth-yl}-4-methyl-7-(pyrimidin-2-yloxy)-chro-men-2-one), C21H18FN5O5S, has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory techniques. Avutometinib crystallizes in space group P1 (#2). The crystal structure is composed of layers parallel to the ab plane. N-H⋯O hydrogen bonds link the layers along the a-axis direction. The mol-ecule is Z-shaped.
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