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Related Experiment Video

Updated: Jun 9, 2026

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review.

Ishleen Oberoi¹, Shabnam Tariq¹, Kristian Arak¹

¹Department of Geriatric Medicine Rotherham General Hospital Rotherham UK.

Chronic Diseases and Translational Medicine

|June 8, 2026

Summary

Frailty increases cardiovascular risk primarily in overweight or obese individuals with unfavorable metabolic profiles. Unintentional weight loss in frail individuals, especially the elderly, does not appear to elevate cardiovascular risk.

Keywords:

cardiovascular disease cardiovascular events cardiovascular risk frailty obesity sarcopenia

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Frailty Assessment in an Aging Mouse Model

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Published on: September 23, 2025

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Last Updated: Jun 9, 2026

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

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Published on: July 26, 2024

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

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Frailty Assessment in an Aging Mouse Model

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Area of Science:

Gerontology
Cardiology
Metabolic Health

Background:

Frailty is an age-related condition linked to increased cardiovascular event risk.
Frailty is heterogeneous, with varying body composition and metabolic profiles, influencing individual cardiovascular risk.
Understanding these variations is crucial for accurate risk assessment.

Purpose of the Study:

To investigate the association between frailty and cardiovascular risk.
To explore how body composition and metabolic profiles modify this association in frail individuals.

Main Methods:

Systematic review of English-language studies over the past 20 years.
Included studies examining frailty, cardiovascular events, body composition, and metabolic profiles.
Analyzed data from 12 studies with 864,294 participants (average age 52-92).

Main Results:

Frailty was a cardiovascular risk factor in 10 of 12 studies.
Positive associations were found in overweight/obese participants with unfavorable metabolic profiles.
Unintentional weight loss was not linked to cardiovascular risk, particularly in the very old.

Conclusions:

Cardiovascular risk associated with frailty is primarily observed in overweight or obese individuals.
Future research should differentiate frailty subtypes based on metabolic profiles for precise risk stratification.
Sarcopenic obese frail individuals, not anorexic malnourished, appear to be at higher cardiovascular risk.