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Updated: Jun 9, 2026
07:34
Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
Published on: March 14, 2013
Metabolomics and ultra-processed foods intake: A scoping review protocol
Talita do Nascimento Peixoto1, Anna Luisa Moura Alencar Rocha2, Lucia Fátima Campos Pedrosa1,2,3
1Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Av. Cordeiro de Farias s/n, Natal 59012-570, RN, Brazil.
Methodsx
|June 8, 2026
Summary
Metabolomics offers insights into how ultra-processed foods (UPFs) affect health, but current research is limited. This review synthesizes evidence on metabolomic studies of UPF consumption to guide future research.
Area of Science:
- Nutrition Science
- Metabolomics
- Public Health
Background:
- The mechanistic link between ultra-processed foods (UPFs) and adverse health outcomes requires further elucidation.
- Metabolomics is a valuable tool for identifying biomarkers and understanding the metabolic impact of UPFs.
- Existing evidence connecting metabolomic profiles to UPF consumption is sparse and inconsistent.
Purpose of the Study:
- To systematically map and synthesize the current scientific literature on metabolomics applied to UPF consumption.
- To characterize the methodologies and study designs utilized in this field.
- To identify existing knowledge gaps and areas for future investigation.
Main Methods:
- A comprehensive scoping review adhering to the JBI methodology and PRISMA-ScR guidelines.
- Systematic literature searches across major databases: PubMed/MEDLINE, Embase, LILACS, and Web of Science.
- Independent screening, data extraction, and narrative synthesis by two reviewers.
Main Results:
- The review will provide a consolidated overview of studies investigating the metabolomic effects of UPF consumption.
- It will highlight the heterogeneity in study designs and methodologies.
- Key knowledge gaps in the field will be identified.
Conclusions:
- This review will offer a comprehensive understanding of the current landscape of metabolomic research on UPFs.
- It will underscore the need for standardized methodologies.
- The findings will inform and direct future research endeavors in this critical area of nutrition and health.
