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Deciphering skeletal muscle development: cellular heterogeneity and molecular regulatory networks from single-cell

Xingdong Wang1,2, Yongming Zhang1,2, Huimin Wei1,2

  • 1College of Life Science and Technology, Inner Mongolia Normal University, Hohhot, China.

Frontiers in Cell and Developmental Biology
|June 8, 2026
PubMed
Summary

This review explores skeletal muscle development, detailing molecular regulators and cellular heterogeneity. Advances in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) reveal conserved and species-specific mechanisms for cell fate regulation.

Keywords:
animal breedingcell fate determinationregulatory networkssingle-cell RNA sequencingskeletal muscle developmentspatial transcriptomics

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