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Updated: Jun 9, 2026

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
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Published on: August 23, 2019

Investigation Into the Variations in the Interactions Between Different Selenium Sources and Gut Microbiota.

Meiyu Yuan1, Yihong Li1, Zixuan Zhou1

  • 1State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province Nanchang University Nanchang China.

Food Science & Nutrition
|June 8, 2026
PubMed
Summary
This summary is machine-generated.

Polysaccharide-stabilized selenium nanoparticles (PS-SeNPs) impact gut bacteria differently based on polysaccharide properties. Positively charged, high molecular weight PS-SeNPs, like chitosan-based ones, promote beneficial bacteria and short-chain fatty acid production.

Keywords:
gut microbiotananoparticlespolysaccharideselenium

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Published on: February 28, 2018

Area of Science:

  • Biochemistry
  • Microbiology
  • Materials Science

Background:

  • Selenium (Se) exists in diverse chemical forms, impacting biological systems.
  • The interaction mechanisms between selenium and gut microbiota are not fully understood.
  • Selenium nanoparticles (SeNPs) offer a novel form for studying Se-gut interactions.

Purpose of the Study:

  • To investigate the effects of different polysaccharide-stabilized Se nanoparticles (PS-SeNPs) on gut microbiota.
  • To determine how polysaccharide molecular properties influence SeNP bioavailability and microbial metabolism.
  • To elucidate the specific microbial communities modulated by various PS-SeNPs.

Main Methods:

  • Utilized an in vitro colonic fermentation model.
  • Systematically evaluated various PS-SeNPs, including chitosan-based variants.
  • Employed metabolomics analysis to assess metabolic pathway activation.

Main Results:

  • Polysaccharide properties (molecular weight, charge) critically affect PS-SeNP gut microbiota modulation.
  • Chitosan-based SeNPs (CS-Se, HACC-Se) enriched beneficial bacteria (Lactobacillus, Bacteroidales), boosting short-chain fatty acids and selenocompound production (selenocystine, Se-Methylselenocysteine).
  • Other PS-SeNPs showed limited bioavailability, while inorganic selenium (H2SeO3) promoted opportunistic pathogens.

Conclusions:

  • Molecular characteristics of polysaccharides are crucial for designing effective SeNPs for gut microbiota modulation.
  • Chitosan-based SeNPs show promise for enhancing beneficial gut bacteria and Se metabolism.
  • Findings advance understanding of Se-microbiota interactions and inform the development of Se-based functional foods or therapeutics.