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Prevalence and Clinical Correlates of Psychiatric Disorders in a Hispanic-Majority Inflammatory Bowel Disease Cohort
Matthew Orosa1, Mindy Xu2, Andrew Chang3
1Internal Medicine, Riverside University Health System Medical Center, Moreno Valley, USA.
Introduction:
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition associated with a substantial burden of psychiatric comorbidity. Depression, anxiety, and other psychiatric disorders are increasingly recognized as important contributors to disease activity, healthcare utilization, and quality of life. However, existing data are largely derived from tertiary care populations, with limited representation of underserved and Hispanic patients.
Methods:
We conducted a single-center, retrospective cohort study of adult patients with IBD within a county health system from 2015 to 2024. The primary outcome was the presence of at least one psychiatric disorder, defined as depression, anxiety, post-traumatic stress disorder, bipolar disorder, psychotic disorders, substance use disorders, or insomnia. Demographic and clinical variables, including age, sex, IBD type, smoking status, and IBD-related hospitalization, were analyzed. Associations were evaluated using Mann-Whitney U testing, chi-square testing, and multivariable logistic regression.
Results:
A total of 158 patients met the inclusion criteria. The prevalence of at least one psychiatric disorder was 48.7%. Depression and anxiety were the most common diagnoses (30.4% each), followed by insomnia (26.6%). The IBD-related hospitalization was significantly associated with psychiatric comorbidity in univariate analysis (54.5% vs. 30.9%, p=0.004). In multivariable analysis, hospitalization was associated with numerically increased odds that did not reach conventional statistical significance (OR 2.32, 95% CI 0.98-5.50, p=0.056).
Conclusions:
Psychiatric disorders are highly prevalent among IBD patients in a county health system, affecting nearly half of the cohort. The IBD-related hospitalization was associated with psychiatric comorbidity in univariate analysis and showed a non-significant trend in multivariable analysis. The results point to the value of coordinated, team-based care models tailored to the needs of underserved communities.
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