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Biliary Tract Carcinoma: Real-World Evidence in a Developing Country.

Mauricio Lema¹, Camila Lema², Beatriz Preciado²

¹Oncology, Clínica de Oncologia Astorga, Medellín, COL.

|June 8, 2026

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This summary is machine-generated.

This study reveals biliary tract carcinoma (BTC) in Colombia has a poor prognosis, with survival outcomes lower than expected, even with standard treatments like gemcitabine-cisplatin. Real-world data highlights challenges for patients and physicians.

Area of Science:

Oncology
Gastroenterology
Epidemiology

Background:

Biliary tract carcinoma (BTC) is an underreported malignancy.
This study addresses the lack of comprehensive data on BTC in Colombia.
It examines clinical characteristics and survival outcomes in a Colombian patient cohort.

Purpose of the Study:

To describe the clinical profile of biliary tract carcinoma patients in Colombia.
To evaluate survival outcomes, including overall survival (OS), event-free survival (EFS), and progression-free survival (PFS).
To identify factors associated with survival in this population.

Main Methods:

An observational, retrospective, multicenter, real-world study.
Data collected on demographics, clinical characteristics, and treatment patterns from six Colombian institutions.

Keywords:

biliary tract neoplasms cholangiocarcinoma gemcitabine neoplasm metastasis progression-free survival survival analysis

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Kaplan-Meier analysis for survival estimation and multivariable Cox regression for prognostic factors.

Main Results:

214 BTC patients included: 47.7% gallbladder, 27.5% extrahepatic, 24.8% intrahepatic.
Median EFS was 16.4 months and median OS was 21.5 months.
Poor prognostic indicators included ECOG performance status ≥2 and elevated CA 19-9 levels (>100 U/mL).

Conclusions:

Colombian BTC patients experience a poor prognosis, even in early stages.
Survival with first-line gemcitabine-cisplatin for advanced BTC is lower than reported in clinical trials.
These real-world findings are crucial for managing patient and physician expectations in Colombia.