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Leveraging antisolvent-processed β-sitosterol to construct a multifunctional curcumin-loaded oleogel for diabetic
Hongyang Guo1,2,3, Shulin Deng3, Caihuan Huang3
1The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Materials Today. Bio
|June 8, 2026
Summary
A novel oleogel system loaded with beta-sitosterol and curcumin effectively treats diabetic wounds by reducing inflammation, oxidative stress, and bacterial load, promoting faster healing.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Nanotechnology
Background:
- Diabetic wound healing is impaired by a complex microenvironment characterized by excessive reactive oxygen species (ROS) and inflammation.
- Current treatments face challenges in regulating this microenvironment to inhibit inflammation, oxidative stress, and bacterial infection.
Purpose of the Study:
- To develop a multifunctional oleogel system for enhanced diabetic wound treatment.
- To investigate the synergistic therapeutic effects of beta-sitosterol and curcumin in promoting diabetic wound healing.
Main Methods:
- Beta-sitosterol particles (AS-Sit) were prepared using anti-solvent precipitation to improve dispersibility.
- A stable oleogel system was formulated by combining AS-Sit with candelilla wax and loading curcumin.
- The oleogel's properties (stability, spreadability, sustained release) and therapeutic efficacy were evaluated.
Main Results:
- The developed oleogel system exhibited excellent stability, spreadability, and sustained-release characteristics.
- The synergistic combination of beta-sitosterol and curcumin in the oleogel (OG/Cur-0.15%) demonstrated significant antibacterial activity.
- The oleogel effectively scavenged ROS, promoted fibroblast migration, induced M2 macrophage polarization, and regulated inflammatory factor expression.
Conclusions:
- The multifunctional oleogel system offers a promising, simple, and effective strategy for treating chronic diabetic wounds.
- This approach addresses key challenges in diabetic wound healing by modulating the wound microenvironment.
- The developed oleogel holds significant potential for future clinical translation in wound care.
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