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Updated: Jun 9, 2026

A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
Published on: May 1, 2013
Mechanism and application of Akkermansia muciniphila in inflammatory diseases
Luyu Xie1, Juane Lu1, Huan Han2
1School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China.
Abstract:
Chronic inflammatory diseases, closely linked to gut microbiota dysbiosis, pose a major global health burden. Akkermansia muciniphila (A. muciniphila), a key gut commensal, sustains immune homeostasis and metabolic balance, emerging as a promising next-generation probiotic. This review synthesizes current evidence on the mechanisms such as regulating the intestinal barrier, immunomodulation, mediating anti-inflammatory metabolites and regulating microbiota and therapeutic potential of A. muciniphila in inflammation-related diseases. Integrating these with experimental/clinical data across inflammation-related disorders establishes a coherent framework. Beyond live bacteria, advances in pasteurized formulations and bioactive derivatives highlight complementary advantages.
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