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Compression of Ribavirin to 35 GPa.

Bhaskar Tiwari1,2, Simon Parsons1, Nico Giordano2

  • 1Centre for Science at Extreme Conditions, School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.

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|June 8, 2026
PubMed
Summary
This summary is machine-generated.

The antiviral drug ribavirin exhibits two crystal forms, V1 and V2. High-pressure studies reveal V1

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Area of Science:

  • Crystallography
  • Materials Science
  • Pharmaceutical Chemistry

Background:

  • Ribavirin, an antiviral medication, exists in two crystalline polymorphs (V1 and V2).
  • The V2 form is thermodynamically stable and easily produced under ambient conditions.
  • The V1 form, denser and less common, is typically obtained via high-pressure, high-temperature methods.

Purpose of the Study:

  • To investigate the structural behavior of the V1 crystalline form of ribavirin under high pressure.
  • To characterize the phase stability and compressibility of ribavirin V1.
  • To understand the compression mechanisms and structural transformations in ribavirin V1.

Main Methods:

  • Recrystallization of ribavirin V1 in a diamond anvil cell under high pressure and temperature.
  • Compression of single crystals of ribavirin V1 to 35.1 GPa.
  • X-ray diffraction analysis to characterize structural changes during compression.

Main Results:

  • The orthorhombic crystal structure (P212121) of ribavirin V1 is maintained up to 35.1 GPa.
  • Distinct changes in structural response were observed around 10.9 GPa and 26.6 GPa.
  • Compression involves interlayer void collapse, layer flattening, and intramolecular conformational adjustments.

Conclusions:

  • Ribavirin V1 retains its orthorhombic phase under significant hydrostatic pressure.
  • The observed structural changes are attributed to void collapse and molecular conformational shifts.
  • Hydrogen-bond topology remains intact, indicating structural resilience in ribavirin V1.