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Published on: December 9, 2010
Compression of Ribavirin to 35 GPa
Bhaskar Tiwari1,2, Simon Parsons1, Nico Giordano2
1Centre for Science at Extreme Conditions, School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.
Crystal Growth & Design
|June 8, 2026
Summary
The antiviral drug ribavirin exhibits two crystal forms, V1 and V2. High-pressure studies reveal V1
Area of Science:
- Crystallography
- Materials Science
- Pharmaceutical Chemistry
Background:
- Ribavirin, an antiviral medication, exists in two crystalline polymorphs (V1 and V2).
- The V2 form is thermodynamically stable and easily produced under ambient conditions.
- The V1 form, denser and less common, is typically obtained via high-pressure, high-temperature methods.
Purpose of the Study:
- To investigate the structural behavior of the V1 crystalline form of ribavirin under high pressure.
- To characterize the phase stability and compressibility of ribavirin V1.
- To understand the compression mechanisms and structural transformations in ribavirin V1.
Main Methods:
- Recrystallization of ribavirin V1 in a diamond anvil cell under high pressure and temperature.
- Compression of single crystals of ribavirin V1 to 35.1 GPa.
- X-ray diffraction analysis to characterize structural changes during compression.
Main Results:
- The orthorhombic crystal structure (P212121) of ribavirin V1 is maintained up to 35.1 GPa.
- Distinct changes in structural response were observed around 10.9 GPa and 26.6 GPa.
- Compression involves interlayer void collapse, layer flattening, and intramolecular conformational adjustments.
Conclusions:
- Ribavirin V1 retains its orthorhombic phase under significant hydrostatic pressure.
- The observed structural changes are attributed to void collapse and molecular conformational shifts.
- Hydrogen-bond topology remains intact, indicating structural resilience in ribavirin V1.
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