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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

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Related Experiment Videos

From Talk to Text: Improving Feedback Concordance With a Simple Intervention.

Rachael Tesorero1, Isabel J Hsu2, Beth Holman3

  • 1Department of Emergency Medicine University of Michigan Ann Arbor Michigan USA.

AEM Education and Training
|June 8, 2026
PubMed
Summary
This summary is machine-generated.

A simple verification question on assessments significantly improved medical student perceptions of feedback concordance. This easy strategy encourages supervisors to provide more actionable feedback to trainees.

Related Experiment Videos

Area of Science:

  • Medical Education
  • Emergency Medicine
  • Healthcare Professional Development

Background:

  • High-quality, actionable feedback is crucial for learner development in emergency medicine (EM).
  • Medical students often report dissatisfaction with feedback due to quantity, vagueness, and discordance between verbal and written elements.
  • Educational scaffolds show potential for improving clinical feedback.

Purpose of the Study:

  • To assess the impact of a "stop and think" verification question on medical student feedback perception.
  • To determine if this intervention improves students' assessment of feedback quality and verbal-written feedback concordance.

Main Methods:

  • A verification question ("I discussed this feedback with the student.") was added to student assessments.
  • Compared pre-intervention (8 months, n=82) and post-intervention (5 months, n=49) assessment data.
  • Analyzed student perception survey data and qualitative feedback content.

Main Results:

  • Student ratings of overall feedback quality remained stable (62% vs. 74%).
  • Significant improvement in reporting verbal-written feedback concordance (72% to 87%, p < 0.001).
  • Proportion reporting >75% concordance increased from 37% to 67%.

Conclusions:

  • A verification question positively impacts student perception of feedback concordance.
  • This intervention does not alter feedback content or actionability.
  • The strategy is easy to implement and encourages supervisors to provide more feedback.