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CIC-DUX4 Rearranged Gastric Sarcoma Confirmed by Next-Generation Sequencing: A Case Report and Review of Literature
Hiroko Hasegawa1, Atsushi Takeno2, Rei Higashiura1
1Department of Gastroenterology and Hepatology NHO Osaka National Hospital Osaka Japan.
None:
This case highlights that gastric CIC-DUX4 rearranged sarcoma is highly aggressive and diagnostically challenging. Early comprehensive genomic profiling was essential for confirming this rare subtype. Despite transient responses to Ewing sarcoma regimens, rapid chemoresistance was observed, emphasizing the need for precise molecular diagnosis and novel therapeutic approaches.
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