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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 9, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Beyond the Triple-Negative Label: A Case Report on Metaplastic Breast Carcinoma.

Samana Oli1, Ayush Sapkota1, Sajjad Ahmed Khan1

  • 1Department of Clinical Oncology Birat Medical College Teaching Hospital Biratnagar Morang Nepal.

Clinical Case Reports
|June 8, 2026
PubMed
Summary

Metaplastic breast carcinoma (MpBC) is a rare and aggressive cancer. Its unique characteristics present significant challenges in diagnosis and treatment for oncologists globally.

Keywords:
metaplastic breast carcinomamultimodal treatmentrare breast malignancysquamous differentiationtriple‐negative breast cancer

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Metaplastic breast carcinoma (MpBC) is a rare subtype of breast cancer.
  • MpBC exhibits aggressive behavior and a poorer prognosis compared to other breast cancer subtypes.
  • Key features include frequent hematogenous spread and a triple-negative phenotype.

Purpose of the Study:

  • To highlight the diagnostic and therapeutic challenges posed by Metaplastic breast carcinoma.
  • To underscore the need for improved understanding and treatment strategies for MpBC.

Main Methods:

  • Review of current oncological literature on Metaplastic breast carcinoma.
  • Analysis of MpBC characteristics, including spread patterns, phenotype, and treatment resistance.

Main Results:

  • MpBC is characterized by predominant hematogenous spread and a high frequency of the triple-negative phenotype.
  • Chemoresistance is a common feature, complicating treatment options.
  • The rarity and poorly defined treatment protocols contribute to its status as a significant clinical challenge.

Conclusions:

  • Metaplastic breast carcinoma presents unique and formidable challenges in clinical oncology.
  • Further research is crucial for developing effective diagnostic and therapeutic protocols for MpBC patients worldwide.