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Updated: Jun 9, 2026
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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Synthetic Polymers for Drug, Gene, and Vaccine Delivery
Yajun Xu1,2, Jie Chen1,2, Jianxun Ding1,2,3
1State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Polymer Science & Technology (Washington, D.C.)
|June 8, 2026
Summary
Synthetic polymers are key for advanced drug, gene, and vaccine delivery systems. This review details their preparation, properties, and therapeutic applications, paving the way for future biomedical innovations.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanomedicine
Background:
- Synthetic polymers are versatile platforms for enhancing therapeutic efficacy and safety.
- They are crucial for advanced drug, gene, and vaccine delivery systems.
- This review focuses on polyesters, polycarbonates, polyanhydrides, polypeptides, and polyethers.
Purpose of the Study:
- To provide a comprehensive overview of synthetic polymers for biomedical applications.
- To discuss their preparation methods, functional properties, and therapeutic benefits.
- To explore advances in gene and vaccine delivery using these polymers.
Main Methods:
- Literature review of synthetic polymers for drug, gene, and vaccine delivery.
- Analysis of preparation methods and functional properties of various polymer classes.
- Synthesis of current knowledge on therapeutic applications and mechanisms.
Main Results:
- Synthetic polymers offer controlled delivery of small molecules, peptides, proteins, DNA, and mRNA.
- Significant therapeutic benefits and specific action mechanisms are highlighted.
- Advances in gene delivery (plasmid DNA, oligonucleotides, mRNA) and vaccine delivery (protein, mRNA) are discussed.
Conclusions:
- Synthetic polymers significantly contribute to modern therapeutics.
- These materials enable enhanced efficacy and safety in drug, gene, and vaccine delivery.
- Future research directions in biomedical fields are identified for synthetic polymer applications.
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