Related Experiment Video
Updated: Jun 9, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023
Current operative approaches for necrotizing enterocolitis
Taylor H Jacobs1, Sarah J Chen1, Colton D Wayne1
1Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease in premature infants. This review covers surgical intervention criteria, procedures, and new methods to improve outcomes for this condition.
Area of Science:
- Neonatal Medicine
- Pediatric Surgery
- Gastroenterology
Background:
- Necrotizing enterocolitis (NEC) is a critical gastrointestinal emergency primarily affecting premature infants.
- It involves severe intestinal inflammation, potentially leading to bowel necrosis, sepsis, and high mortality rates.
- Current management relies on supportive care, with surgery indicated for refractory cases.
Purpose of the Study:
- To review the indications for surgical intervention in necrotizing enterocolitis.
- To describe common surgical procedures for NEC.
- To discuss emerging perioperative strategies aimed at enhancing patient outcomes.
Main Methods:
- Literature review focusing on surgical management of NEC.
- Analysis of decision-making processes for surgical intervention.
- Examination of current and novel surgical techniques and adjuncts.
Main Results:
- Established criteria for determining the necessity of surgery in NEC.
- Detailed descriptions of surgical approaches, including laparotomy and minimally invasive techniques.
- Overview of innovative perioperative adjuncts and their potential impact on NEC outcomes.
Conclusions:
- Surgical intervention is a critical component in managing severe necrotizing enterocolitis.
- Standardized approaches to surgical decision-making and procedural execution are essential.
- Ongoing research into perioperative adjuncts holds promise for improving survival and reducing morbidity in affected infants.
Related Concept Videos
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
Aneurysm IV: Nursing Management
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Acute Pyelonephritis II: Diagnostic Studies and Management