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Published on: November 25, 2013

PERFECTA Loaded Lipid Cubosomes for ¹⁹F-MRI: Physico-Chemical Characterization.

Pietro Milesi¹, Beatrice Lucia Bona¹, Cristina Chirizzi²

¹Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Milano, Italy.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|June 8, 2026

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Phytantriol-based cubosomes loaded with the PERFECTA probe were developed as novel 19F-MRI nanoprobes. These stable nanotheranostic platforms show great promise for biomedical imaging and drug delivery applications.

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Liquid crystalline nanoparticles (LCNPs), including cubosomes, offer unique structures for drug delivery and bioimaging.
Phytantriol-based cubosomes are biocompatible and possess tunable properties.

Purpose of the Study:

To develop and characterize phytantriol-based cubosomes loaded with the PERFECTA fluorinated probe.
To evaluate their potential as 19F-MRI nanoprobes for biomedical applications.

Main Methods:

Solvent evaporation synthesis of PERFECTA-loaded cubosomes.
Characterization using DLS, SAXS, Cryo-TEM, DSC, 19F-NMR, and 19F-MRI.
Assessment of colloidal stability in biological media.

Main Results:

Keywords:

19F NMR/MRI PERFECTA lipid self‐assembly liquid crystalline nanoparticles

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Cubosomes maintained the Pn3m cubic phase with over 70% encapsulation efficiency for PERFECTA.
Cryo-TEM showed PERFECTA segregation into spherical domains within or outside cubosomes.
Excellent colloidal stability was observed in biological media for 24 hours.
Favorable relaxometric properties and robust 19F MRI signals were achieved.

Conclusions:

PERFECTA-loaded cubosomes are stable and efficient nanotheranostic platforms.
They demonstrate significant potential for advanced biomedical imaging and targeted drug delivery.
The developed nanoprobes offer a promising tool for 19F-MRI applications.