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Related Experiment Video

Updated: Jun 9, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

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Y-90 Radioembolization Through Aberrant Arterial Supply: Four-Case Experience.

Seyma Omay1, Mustafa Fatih Arslan2, Burcu Esen Akkas1

  • 1Department of Nuclear Medicine.

Clinical Nuclear Medicine
|June 8, 2026
PubMed
Summary

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Hepatic Y-90 radioembolization (RE) can be safely performed using aberrant arterial feeders in selected liver cancer patients. Careful prevention of extrahepatic leakage ensures effective treatment for tumors with unusual vascularization.

Area of Science:

  • Interventional Radiology
  • Hepatobiliary Oncology
  • Vascular Imaging

Background:

  • Hepatic vascular anatomy frequently exhibits variations.
  • Limited data exists on Y-90 radioembolization (RE) through nonhepatic arterial feeders.
  • Aberrant tumor vascularization can complicate RE, sometimes leading to TACE or treatment abandonment.

Purpose of the Study:

  • To evaluate the safety and efficacy of Y-90 RE using aberrant arterial feeders in liver lesions.
  • To assess the feasibility of RE in tumors with non-standard hepatic vascular supply.
  • To highlight the importance of recognizing and managing extrahepatic arterial feeders.

Main Methods:

  • Retrospective case series analysis of patients undergoing Y-90 RE.
  • Identification and selective catheterization of aberrant hepatic and extrahepatic arterial feeders.
Keywords:
aberrant arterymicrosphereradioembolization

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  • Careful procedural planning to prevent extrahepatic radioactive microsphere leakage.
  • Assessment of treatment response and complications.

    • Main Results:

    • Y-90 RE was successfully and safely performed using aberrant feeders in selected patients.
    • Effective tumor treatment was achieved without significant extrahepatic leakage.
    • This approach offers an alternative for patients with complex hepatic vascular anatomy.

    Conclusions:

    • Y-90 radioembolization is a viable and effective treatment option for liver tumors with aberrant vascularization when using nonhepatic feeders.
    • Meticulous attention to preventing extrahepatic leakage is crucial for successful outcomes.
    • This technique expands treatment possibilities for complex hepatobiliary malignancies.