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Three new compounds from Nardostachys jatamansi.
Xiao-Ying Li1, Bo Pang1,2, Zhi-Cheng Yao2
1School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 117004, China.
Journal of Asian Natural Products Research
|June 8, 2026
Summary
Three new compounds and three known sesquiterpenoids were isolated from Nardostachys jatamansi roots. Compounds 1, 2, and 6 showed neuroprotective effects against glutamate-induced neurotoxicity in neuronal cells.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Neuroscience
Background:
- Nardostachys jatamansi is a medicinal plant with a history of traditional use.
- Sesquiterpenoids are a class of natural products with diverse biological activities.
- Neurodegenerative diseases pose a significant global health challenge.
Purpose of the Study:
- To isolate and characterize chemical constituents from Nardostachys jatamansi roots.
- To evaluate the neuroprotective potential of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using comprehensive spectroscopic methods (MS, IR, NMR).
- Assessment of neuroprotection against glutamate-induced cytotoxicity in SH-SY5Y cells.
Main Results:
- Three new compounds ((8S)-neonardochinone B, 4-methylocta-2,4,6-trienedioic acid, narchinol D) and three known sesquiterpenoids (kanshones A, K, L) were identified.
- Compounds 1, 2, and 6 exhibited significant neuroprotective effects at 10 µM.
- Glutamate-induced cytotoxicity in SH-SY5Y neuronal cells was counteracted by these compounds.
Conclusions:
- Nardostachys jatamansi is a source of novel sesquiterpenoids with potential therapeutic applications.
- Compounds 1, 2, and 6 show promise as neuroprotective agents.
- Further investigation into the mechanisms of action is warranted.
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