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Updated: Jun 9, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
[Autoimmune pancreatitis and IgG4-related disease]
1Institut für Molekulare Onkologie und Stammzellbiologie, Uniklinik Ulm, Ulm, Deutschland. alexander.kleger@uni-ulm.de.
None:
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated systemic disease that causes organ-specific inflammation and fibrosis patterns and also frequently has tumor-like effects. In the pancreaticobiliary setting type 1 autoimmune pancreatitis (AIP1) and IgG4-related cholangitis (IAC) are the most important manifestations. Structured diagnostics are decisive, with prioritized exclusion of malignancies and infections followed by a syndrome-based classification (serology, imaging, histology and organ pattern). Glucocorticoids are highly effective for induction of remission; however, recurrences are frequent and require a risk-adapted prevention of recurrence and structured monitoring of the course.
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