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Related Experiment Video

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Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.

Veronica Mohamed Hizam1, Di Prisco Stefania2, Anna Pisani3

  • 1Department of Head and Neck Surgery, Università Cattolica del Sacro Cuore, Rome, 00168, Italy.

Cellular and Molecular Neurobiology
|June 8, 2026
PubMed
Summary

Neurotrophins are key for sensory neuron health and repair. Therapies targeting these proteins show promise for restoring vision, hearing, and smell, despite delivery challenges.

Keywords:
NeuroprotectionNeurotrophinsSensory neuropathiesTherapy

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Sensory Biology

Background:

  • Neurotrophins (NGF, BDNF, NT-3) regulate neuronal survival, plasticity, and regeneration.
  • Sensory systems (auditory, visual, olfactory) rely on neurotrophin signaling for integrity and repair.
  • Dysfunction in these systems is linked to neurotrophin signaling deficits.

Purpose of the Study:

  • To review the role of neurotrophins in maintaining sensory neuronal integrity.
  • To examine molecular mechanisms of neurotrophin action in sensory pathways.
  • To compare neurotrophin-based therapies with emerging regenerative strategies.

Main Methods:

  • Literature review focusing on neurotrophin roles in sensory systems.
  • Analysis of molecular mechanisms in cochlear, optic, and olfactory dysfunction.
  • Comparative assessment of therapeutic approaches.

Main Results:

  • Neurotrophins are vital for neuronal survival and synaptic plasticity.
  • Specific neurotrophin deficits are implicated in cochlear synaptopathy, optic neuropathy, and olfactory dysfunction.
  • Neurotrophin therapies show potential but face delivery and pharmacokinetic challenges.

Conclusions:

  • Neurotrophin-based interventions are promising for sensory function restoration.
  • Integration with complementary regenerative approaches enhances therapeutic potential.
  • Further research is needed to overcome clinical translation hurdles for neurotrophin therapies.