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Correction: Radiotherapy for intramedullary, leptomeningeal and epidural metastases: outcomes of an unusual and ominous complication.

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Related Experiment Video

Updated: Jun 9, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Risk factors and long-term outcomes in smart syndrome: a multicenter study.

Maria Bea Sintes1, Gabriel Velilla-Alonso2, Alejandro Herrero-San Martin2

  • 1Unitat de Neuro-Oncologia, Hospital Universitari de Bellvitge- ICO Hospitalet- Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), C/Feixa Llarga S/N, L'Hospitalet del Llobregat, Barcelona, 08097, Spain.

Journal of Neuro-Oncology
|June 8, 2026
PubMed
Summary

Severe Stroke-like Migraine Attacks after Radiotherapy (SMART) episodes are common, particularly in males with longer radiotherapy latency. Cortical FLAIR hyperintensity and longer first episodes reduce recurrence, but status epilepticus worsens survival.

Keywords:
Cranial radiotherapyLong-term outcomesMigraineRecurrenceSMART

Related Experiment Videos

Last Updated: Jun 9, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Area of Science:

  • Neurology
  • Oncology
  • Radiotherapy

Background:

  • Stroke-like Migraine Attacks after Radiotherapy (SMART) is a rare, late-onset complication of cranial radiotherapy.
  • It presents as episodes of neurological dysfunction with migraine-type headaches.

Purpose of the Study:

  • To identify factors associated with the severity of the first SMART episode.
  • To determine factors influencing recurrence and overall survival in SMART patients.

Main Methods:

  • Retrospective review of patients diagnosed with modified SMART criteria between 2010-2023 from nine Spanish hospitals.
  • Analysis of demographic, clinical, neuroimaging, treatment, and outcome data.

Main Results:

  • Thirty-one patients were included; 61% experienced severe initial episodes.
  • Male sex and longer latency post-radiotherapy were linked to severe presentations.
  • Cortical FLAIR hyperintensity and longer episode duration correlated with lower recurrence; status epilepticus and tumor factors predicted poorer survival.

Conclusions:

  • SMART syndrome exhibits heterogeneous long-term outcomes.
  • Severe initial episodes are frequent, especially in males with longer radiotherapy latency.
  • Predictors for recurrence and survival were identified, aiding in patient management.