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Updated: Jun 9, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus

Akanksha Saini1, Zaid Bashir1, Dinesh Kumar Mehta1

  • 1M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India.

Journal of Cardiovascular Translational Research
|June 8, 2026
PubMed

Insights

Gamma-glutamyl transferase (GGT) shows promise as a cardiac marker. Elevated GGT levels correlate with cardiovascular disease risk factors and outcomes, aiding in risk prediction and patient management.

Area of Science:

  • Biochemistry
  • Cardiology
  • Biomarkers

Background:

  • Glutathione metabolism involves gamma-glutamyl transferase (GGT).
  • GGT is increasingly linked to cardiovascular diseases (CVD).
  • Elevated GGT is associated with heart failure, coronary artery disease, and adverse cardiovascular outcomes.

Purpose of the Study:

  • To evaluate serum GGT as a cardiac marker for detecting various cardiac diseases.
  • To assess the clinical utility of GGT in cardiovascular medicine.
  • To explore GGT's role in cardiovascular risk prediction.

Main Methods:

  • The study analyzed the correlation between serum GGT levels and cardiovascular disease markers.
  • Investigated the association of GGT with established CVD risk factors.
  • Evaluated GGT's predictive value for acute coronary syndromes and myocardial infarction.

Main Results:

  • Elevated GGT levels correlate with heightened risk of heart failure, coronary artery disease, and acute coronary events.
  • GGT levels are associated with CVD risk factors like diabetes, hypertension, and metabolic syndrome.
  • Serum GGT is a promising biomarker for cardiovascular risk prediction, disease severity assessment, and prognosis.

Conclusions:

  • Serum GGT is a valuable biomarker for cardiovascular risk assessment.
  • GGT can aid in evaluating disease severity and prognosis in patients with CVD.
  • GGT holds potential for preventive cardiology and personalized medicine in CVD management.

Keywords:
BiomarkerCardiovascular DiseasesCoronary DiseasesGamma-Glutamyl TransferaseMyocardial Infarction

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