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Acute symptomatic seizures after accidental intrathecal lidocaine administration: A case series
Luciano Pellegrino1, Giulia Bruschi2, Rossana Ragone3
1Department of Neuroscience, University of Padua, Padua, Italy. luciano.pellegrino@aulss6.veneto.it.
Introduction:
Lidocaine (LA) is a widely used local anaesthetic and analgesic, and a potential therapeutic option for status epilepticus; however, due to its neurotoxicity, it also carries an associated risk of inducing life-threatening seizures and other neurological conditions. The semiology and the treatment of these provoked seizures remain poorly understood.
Objectives:
To better understand the seizure-related behaviour, clinical presentation and electroencephalographic patterns associated to lidocaine-induced seizures.
Methods:
In this paper we describe three cases of inadvertent intrathecal LA administration for chronic lumbar pain focusing on clinical presentation, laboratory and neuroimaging findings.
Conclusions:
Acute symptomatic seizures may represent an adverse reaction to intrathecal lidocaine administration and may present with TNS and alteration of consciousness, leading to status epilepticus. A prompt initiation of antiseizure therapy should be considered to ensure the best outcome.
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