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Targeting programmed cell death: a novel therapeutic paradigm for cancer based on mode-of-death classification
Xi Qiao1,2, Ting Ye1,3, Tinggai Wu1,3
1Henan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Summary
Programmed cell death (PCD) pathways are vital for homeostasis and cancer treatment. This review proposes a framework to target diverse PCD patterns, optimizing combination therapies for enhanced cancer treatment strategies.
Area of Science:
- Oncology
- Cell Biology
- Molecular Biology
Background:
- Programmed cell death (PCD) encompasses multiple pathways (apoptosis, autophagy, cuproptosis, ferroptosis, necroptosis, paraptosis, pyroptosis).
- These pathways are critical for maintaining cellular homeostasis and are implicated in various diseases, including cancer.
Purpose of the Study:
- To propose an integrated framework for classifying PCD pathways based on death patterns.
- To systematically analyze the strategic significance of targeting PCD in cancer therapy.
- To explore the design of therapeutic strategies tailored to specific PCD patterns and their interactions.
Main Methods:
- Systematic review of programmed cell death pathways.
- Development of a novel classification framework based on cell death patterns.
- Analysis of cross-talk and synergistic effects among different PCD pathways.
Main Results:
- An integrated framework for understanding and targeting PCD pathways in cancer.
- Identification of therapeutic strategies for diverse PCD patterns.
- Emphasis on the crucial role of inter-pathway cross-talk in combination therapies.
Conclusions:
- Targeting PCD networks offers a promising avenue for developing next-generation cancer treatments.
- Understanding the interplay between PCD pathways is essential for designing effective combination regimens.
- This review provides a foundation for future research in precision cancer therapy through PCD modulation.
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