Related Experiment Video
Updated: Jun 9, 2026
07:03
A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
Published on: June 16, 2022
From force to resorption: mechanotransduction, osteoclasts, prevention
Fulong Shen1, Xiaohui Xia1, Yineng Han1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Progress in Orthodontics
|June 8, 2026
Summary
Orthodontically induced root resorption (OIRR) is a common complication of braces. This review details the cellular and molecular pathways driving OIRR, focusing on osteoclast activity and potential therapeutic strategies.
Area of Science:
- Biomedical Engineering
- Orthodontics
- Cell Biology
Background:
- Orthodontically induced root resorption (OIRR) is a frequent, irreversible complication of orthodontic treatment.
- It involves pathological hard root tissue loss due to mechanical loading, influenced by force variables and patient biology.
- Osteoclasts are key effectors, creating a pro-resorptive microenvironment with other periodontal cells.
Purpose of the Study:
- To synthesize current knowledge on molecular and cellular cascades linking orthodontic force to OIRR.
- To examine intercellular communication in tissue breakdown during OIRR.
- To appraise diagnostics and evaluate therapeutic strategies for OIRR.
Main Methods:
- Literature review synthesizing current knowledge on OIRR.
- Analysis of molecular and cellular pathways involved in osteoclast activation.
- Evaluation of diagnostic and therapeutic strategies for OIRR.
Main Results:
- Mechanical signals trigger biochemical cues engaging osteoclastogenesis pathways (e.g., RANK/RANKL).
- Modulatory processes like epigenetics, autophagy, ROS dynamics, and ECM remodeling influence OIRR.
- Systemic factors (hormonal, metabolic, genetic) impact susceptibility and treatment response.
Conclusions:
- Osteoclasts are central to OIRR, driven by complex molecular and cellular networks.
- Emerging diagnostics and targeted therapies (e.g., osteoclast inhibitors, biomaterials) show promise.
- Future research should utilize multi-omics and local delivery systems for OIRR management.
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