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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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High-density lipoprotein antioxidant function is associated with lipid profiles and lipid-lowering therapy

Hong-Yu Cao1,2, Zhi-Wei Mo1,2, Zhen-Sheng Ma1,2

  • 1Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

Science China. Life Sciences
|June 8, 2026
PubMed

Insights

High-density lipoprotein (HDL) antioxidant function is linked to lipid profiles in coronary artery disease (CAD) patients. Lipid-lowering therapy enhances HDL antioxidant function, suggesting its potential as a treatment efficacy indicator.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Clinical Chemistry

Background:

  • Dyslipidemia is a key risk factor for coronary artery disease (CAD).
  • The role of high-density lipoprotein (HDL) antioxidant function in CAD and its interaction with lipid-lowering therapy requires further investigation.
  • Understanding HDL's antioxidant capacity is crucial for managing CAD patients.

Purpose of the Study:

  • To analyze the association between HDL antioxidant function, lipid profiles, and lipid-lowering therapy in CAD patients.
  • To evaluate HDL antioxidant function as a predictor of CAD.
  • To explore the impact of lipid-lowering therapy on HDL antioxidant function.

Main Methods:

  • Recruited 1,000 CAD patients and 200 healthy controls.
  • Measured HDL lipid peroxide content, normalized by HDL cholesterol (HDL-C) to define HDL antioxidant function (nHDLox).
  • Analyzed associations between nHDLox, lipid profiles, CAD severity, lipid-lowering therapy, fasting blood glucose, and inflammatory markers.

Main Results:

  • nHDLox levels were elevated in CAD patients and correlated with CAD severity.
  • nHDLox demonstrated superior predictive value for CAD compared to triglyceride-glucose index and HDL-C.
  • nHDLox positively correlated with total cholesterol, LDL-C, triglycerides, fasting blood glucose, and inflammatory markers.
  • Lipid-lowering therapy was associated with improved HDL antioxidant function in CAD patients with controlled LDL-C.

Conclusions:

  • HDL antioxidant function is significantly associated with lipid profiles and inflammatory markers in CAD.
  • nHDLox can serve as a potential biomarker for CAD prediction and monitoring treatment efficacy.
  • Lipid-lowering therapy appears to enhance HDL antioxidant function in CAD patients.

Keywords:
coronary artery diseasehigh-density lipoproteinlipid peroxidationlipid profileslipid-lowering therapy

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