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Related Experiment Video

Updated: Jun 10, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

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Published on: March 12, 2022

Retinal microvascular alterations in children with amblyopia.

Christiane Al-Haddad1, Hanadi Ibrahim1, Nagib Salameh1

  • 1Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon.

Plos One
|June 8, 2026
PubMed
Summary

Amblyopic eyes show increased macular vessel and perfusion densities compared to controls. Fellow eyes have a smaller foveal avascular zone than amblyopic eyes, suggesting subtle microvascular changes in amblyopia.

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Published on: May 26, 2023

Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Vascular Biology

Background:

  • Amblyopia, or 'lazy eye', is a developmental disorder affecting visual acuity.
  • Retinal microvasculature alterations may play a role in amblyopia.
  • Optical coherence tomography angiography (OCTA) allows non-invasive visualization of retinal vasculature.

Purpose of the Study:

  • To compare retinal vascular parameters in amblyopic, fellow, and control eyes.
  • Investigate superficial macular vessel density, foveal avascular zone, and macular perfusion densities.
  • Utilize optical coherence tomography angiography (OCTA) for detailed analysis.

Main Methods:

  • Prospective cross-sectional study of 78 participants (36 amblyopic, 42 controls).
  • Comparison of amblyopic eyes versus control and fellow eyes using OCTA.
  • Analysis included macular and optic disc vascular parameters.

Main Results:

  • Amblyopic eyes exhibited higher macular vessel and perfusion densities compared to controls.
  • A smaller foveal avascular zone was observed in amblyopic eyes versus fellow eyes.
  • Optic disc OCTA parameters were comparable between amblyopic and control eyes.

Conclusions:

  • Amblyopia is associated with increased macular vascular and perfusion densities and a smaller foveal avascular zone.
  • No significant optic disc microvascular differences were detected.
  • Further research with larger cohorts is needed to confirm these subtle macular microvascular alterations in amblyopia.