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Updated: Jul 1, 2026
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
Stroke-Related Animal Models: Methodologies, Applications, and Translational Perspectives
Chenglong Shi1, Mengyuan Xu2, Yanmei Li3
1Department of Psychiatric Sleep Medicine Center, the Second Affiliated Hospital of Kunming Medical University; Department of Neurosurgery, the Second Affiliated Hospital of Kunming Medical University.
This review details diverse experimental stroke models, from ischemic to hemorrhagic types, highlighting their use in developing new neuroprotective therapies. Improving animal model relevance to human stroke is key for successful clinical translation.
Area of Science:
- Neuroscience
- Translational Medicine
- Neurology
Background:
- Stroke is a major global cause of death and disability.
- Preclinical neuroprotective agents frequently fail in clinical trials due to model limitations.
- Existing animal models do not fully replicate human stroke complexity.
Purpose of the Study:
- To provide a comprehensive review of experimental stroke models.
- To critically evaluate the technical aspects, benefits, and drawbacks of each model.
- To guide the selection and design of more translatable stroke research.
Main Methods:
- Systematic review of various stroke models: ischemic, hemorrhagic, cerebrovascular, spontaneous, and special conditions.
- Analysis of technical approaches, parameters, advantages, and limitations.
- Emphasis on adherence to STAIR and ARRIVE guidelines for rigorous study design.
Main Results:
- Detailed overview of models for studying neuroprotection, reperfusion, hematoma expansion, inflammation, BBB disruption, and rehabilitation.
- Highlights the need for controlling variables like species, strain, sex, age, and comorbidities.
- Identifies critical outcome measures aligned with clinical scenarios.
Conclusions:
- Developing hybrid and comorbidity-integrated models is essential for human stroke heterogeneity.
- Cross-species validation, advanced biomarkers, and translational platforms are crucial.
- Bridging the gap between animal models and clinical trials is vital for effective stroke therapy discovery.
