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Severe Morbidity and Mortality From Coronavirus Disease 2019 in Hmong Individuals With Gout
Kari Falaas1, Michael Schnaus2,3, Elie Gertner2
1University of Minnesota Medical School, Minneapolis, Minnesota, falaa002@umn.edu.
Insights
Severe outcomes and high mortality were observed in Hmong patients with gout and COVID-19. This highlights potential disparities in care and the impact of comorbidities on coronavirus disease 2019 outcomes in this population.
Area of Science:
- Infectious Diseases
- Public Health
- Genetics and Genomics
Background:
- Coronavirus disease 2019 (COVID-19) disproportionately affects patients with comorbidities like gout.
- Diverse populations, including the Hmong community, experience unique challenges with COVID-19.
- The combined impact of gout and ethnicity on COVID-19 severity is not well understood.
Purpose of the Study:
- To investigate COVID-19 outcomes in Hmong patients with coexisting gout.
- To assess the severity and mortality rates in this specific patient group.
Main Methods:
- Retrospective review of 21 Hmong patients with gout and COVID-19.
- Data collected from two tertiary care centers between March 2020 and December 2021.
Main Results:
- Nearly half (48%) of patients required mechanical ventilation.
- A significant 30-day mortality rate of 57% was observed.
- Various levels of respiratory support were needed, from low-flow oxygen to mechanical ventilation.
Conclusions:
- Hmong patients with gout experienced a high burden of severe COVID-19 outcomes.
- High mortality rates suggest potential roles for comorbidities, vaccination disparities, and structural factors.
- Further research is needed to address health disparities and improve outcomes in vulnerable populations.
Background:
Given the disproportionate impact of coronavirus disease 2019 (COVID-19) on patients with comorbidities - including gout - and on diverse populations such as the Hmong community, it remains unclear whether a combination of these factors lead to more severe COVID-19 outcomes.
Methods:
We reviewed the outcomes of 21 Hmong patients with coexisting gout and COVID-19 admitted to 2 tertiary care centers from March 1, 2020, through December 31, 2021.
Results:
Seven patients required low-flow nasal cannula oxygen, 3 required high-flow nasal cannula, 1 required noninvasive ventilation, and 10 (48%) required mechanical ventilation. The 30-day mortality rate was 57% (n=12).
Discussion:
The findings highlight a potentially disproportionate burden of severe COVID-19 outcomes among Hmong patients with gout. The high observed mortality raises questions about the role of comorbidities, vaccination disparities, and structural factors contributing to poor outcomes in this population.
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