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Microparticles Based on Polycaprolactone, Xanthan Gum, and Chrysophanol: Optimization, Characterization,
Thuy Chinh Nguyen1,2, Thanh Dat Nguyen1, Dinh Thang Tran3
1Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Ha Noi 100000, Vietnam.
Langmuir : the ACS Journal of Surfaces and Colloids
|June 8, 2026
Summary
This study optimized poly(caprolactone) and xanthan gum microparticles for chrysophanol delivery. The resulting PXC microparticles show potential for biomedical applications due to stability and controlled release.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Emulsion-derived microparticles are vital for delivering poorly water-soluble drugs.
- Optimizing component ratios is key for stability and controlled release in drug delivery systems.
Purpose of the Study:
- To develop and characterize poly(caprolactone)/xanthan gum (PCL/XG) microparticles for chrysophanol (CHR) delivery.
- To investigate the impact of component ratios on emulsion system stability and droplet size.
- To evaluate the physicochemical, pharmacological, and drug release properties of the developed microparticles.
Main Methods:
- Emulsion method using PCL, xanthan gum (XG), and Tween 80 to encapsulate chrysophanol (CHR).
- Optimization of component ratios for system stability and droplet size.
- Characterization of PCL/XG/CHR (PXC) microparticles using SEM, ζ-potential, size distribution, FTIR, DSC, and XRD.
- Assessment of physicochemical, pharmacological properties, and drug release profiles.
Main Results:
- Optimized PCL/XG/CHR (PXC) microparticles were successfully prepared.
- CHR transitioned from crystalline to amorphous form within the microparticles.
- Drug release was found to be pH-sensitive and controllable via drug-polymer interactions.
- PXC microparticles exhibited high stability, good release profile, nontoxicity, and biological activity.
Conclusions:
- Emulsion-derived PCL/XG microparticles offer a promising platform for delivering poorly water-soluble drugs like chrysophanol.
- The developed PXC microparticles demonstrate potential for biomedical applications owing to their favorable characteristics.
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