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Lactones as inhibitors of the fibrinolytic system
Science (New York, N.Y.)
|June 2, 1967
Abstract:
Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.